Immunology Scientist

Based in Rochester, MN, we are seeking a talented and passionate Immunology Scientist to join our cutting-edge biotech company focused on revolutionizing cancer therapeutics through immuno-oncology research. As an Immunology Scientist, you will be at the forefront of our efforts to develop innovative immunotherapies to combat various forms of cancer. Your expertise in immunology, cell biology, and oncology will be pivotal in driving research projects, identifying novel therapeutic targets, and advancing our pipeline of potential breakthrough treatments.

Salary is commensurate with experience and qualifications. A comprehensive benefits package including:
Paid Holidays
PTO
Health insurance
Employer-paid Short and Long Term Disability
Life Insurance
AD&D
Dental/ Vision Insurance
Simple IRA with an employer match
Sign-on bonus of $5,000


Work visa sponsorship is not available for this position.

Key Responsibilities
Design and perform independent experiments in tissue culture, and viral infections in rodent tumor models. Execute experiments from set up to take down, and downstream cellular analysis.
The position will play a critical role in the generation of new vector constructs and troubleshooting the vector expression in CAR T cells.
Design, generate, and characterize CAR or other constructs for genetically modified T cells.
Independently design and lead pre-clinical in-life studies including downstream analysis.
Collect, analyze, and present scientific data to the research and management teams; with proposed next steps.
Self-motivated and driven to work independently and collaboratively as part of a team.
Coordinate research efforts and make key scientific and technical contributions for the strategic development of cross-functional projects.
The candidate will perform independent experimental research but will work in close collaboration with the rest of the scientific team in a highly cross-functional and project-oriented environment.

Qualifications / skills
PhD or Master degree in Immunology or a related field with a minimum of 3 years of industry or academic experience in immunology and in vivo oncology or pharmacology.
Exceptional laboratory skills, with demonstrated proficiency in the development and execution of primary immune cell assays (T cell and/or myeloid cell).
Deep understanding of adaptive immunity including T cell, B cell, myeloid or dendritic cell biology.
Working knowledge of all stages of CAR design and virus generation.

Valued Complementary Skills
T-cell activation assay (Mouse or human)
T-cell memory response recall assays: ELISPOT
Immunophenotyping: Multiplex and tetramer analysis
Immunohistochemistry, with focus on T cell markers (Multiplex)
RNAscope
Handling and processing human PBMC samples
Processing of mouse spleen, Lymph nodes for downstream analysis
Additional preferred qualifications: RNAseq analysis, Exome sequencing